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A workflow is locked under the following conditions:
When a node is running, the workflow is locked, and none of its nodes can be edited. Existing results may be viewed while the workflow is running. You can also go to a different workflow and edit or run it.
When a user opens a workflow, the workflow is locked so that other users cannot modify it.
When a workflow is running, an animation in the tool bar (circular arrow loop) shows that the workflow is running.
When you open a locked workflow, Locked is displayed in the tool bar and a running indicator if the workflow is running:

If no one else has the workflow locked, and you are given the lock, then lock icon is removed from the tool bar.
Unlocking a locked workflow: If a workflow seems to complete, but is still locked, click Locked to unlock the workflow.
Refreshing Workflow: Once a locked workflow has stopped running, you can refresh the workflow by clicking the
icon. You can also try to obtain the lock yourself by clicking on the lock.